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Tamapin
簡(jiǎn)要描述：Smartox Biotechnology是*一家專(zhuān)門(mén)生產(chǎn)動(dòng)物毒液多肽毒素，用于細(xì)胞離子通道功能研究的生物醫(yī)藥公司。多肽毒素在生物制藥領(lǐng)域具有重要的使用價(jià)值。
產(chǎn)品型號(hào)：10TAM001- 廠商性質(zhì)：代理商
- 更新時(shí)間：2024-10-30
- 訪 問(wèn) 量：1549
產(chǎn)品介紹
Tamapin
Selective blocker of SK2 (KCa2.2) channels
SK2 (KCa2.2)通道選擇性阻斷劑
Tamapin is a peptide toxin isolated from the venom of the Indian red scorpion Mesobuthus Tamulus. is amidated at its C-terminal tyrosine residue. binds to small conductance Ca2+-activated K+ channels (SK channels) with high affinity and inhibits SK channel-mediated currents in pyramidal neurons of the hippocampus as well as in cell lines expressing distinct SK channel subunits. Contrary to Apamin or Leiurotoxin-1 (Scyllatoxin), is an excellent toxin to discriminate among SK channel subtypes because it presents different affinities for SK1 (42 nM), SK2 (24 pM) and SK3 (1.7 nM) channels. This toxin is also the most potent SK2 channel blocker characterized so far (IC50 for SK2 channels = 24 pM).
技術(shù)資料
氨基酸序列：
Ala-Phe-Cys3-Asn-Leu-Arg-Arg-Cys8-Glu-Leu-Ser-Cys12-Arg-Ser-Leu-Gly-Leu-Leu-Gly-Lys-Cys21 -Ile-Gly-Glu-Glu-Cys26-Lys -Cys28-Val-Pro-Tyr-NH2
二硫鍵： Cys3-Cys21; Cys8-Cys26; Cys12-Cys28
長(zhǎng)度（aa）： 31
分子式：C146H237N44O41S6
分子量： 3459.00 Da
外觀：White lyophilized solid
可溶性： water and saline buffer
CAS號(hào)： not available
來(lái)源：Synthetic
純度：> 97 %
產(chǎn)品信息
10TAM001-00100 | 0.1mg | |
10TAM001-00500 | 0.5mg | |
10TAM001-01000 | 1mg |
